Amoxicillin (INN) or amoxycillin (BAN) is a moderate-spectrum, bacteriolytic, β-lactam antibiotic used to treat bacterial infections caused by susceptible microorganisms. It is usually the drug of choice within the class because it is better absorbed, following oral administration, than other beta-lactam antibiotics. Amoxicillin is susceptible to degradation by β-lactamase-producing bacteria, and so may be given with clavulanic acid to decrease its susceptibility.

Mode of action
Amoxicillin acts by inhibiting the synthesis of bacterial cell walls. It inhibits cross-linkage between the linear peptidoglycan polymer chains that make up a major component of the cell wall of Gram-positive bacteria.

Category: Tag:



Amoxicillin is a moderate-spectrum antibiotic active against a wide range of Gram-positive, and a limited range of Gram-negative organisms. Some examples of susceptible and resistant organisms, from the Amoxil Approved Product Information (GSK, 2003), are listed below.

Susceptible Gram-positive organisms
— Streptococcus spp.
— penicillin-susceptible Streptococcus pneumoniae
— non β-lactamase-producing Staphylococcus spp.
— Enterococcus faecalis.

Susceptible Gram-negative organisms
Non-β-lactamase producing strains of the following bacteria:
— Haemophilus influenzae
— Neisseria gonorrhoeae
— Neisseria meningitidis
— Escherichia coli
— Proteus mirabilis
— Salmonella spp.

Resistant organisms
Penicillinase-producing organisms, particularly penicillinase-producing Staphylococcus spp. Penicillinase-producing N. gonorrhoeae and H. influenzae are also resistant.

All strains of Pseudomonas spp., Klebsiella spp., Enterobacter spp., indole-positive Proteus spp., Serratia marcescens, and Citrobacter spp. are resistant.

The incidence of β-lactamase-producing resistant organisms, including E. coli, appears to be increasing. Doctors may opt to prescribe co-amoxiclav, amoxicillin combined with β-lactamase inhibitor potassium clavulanate, instead of just amoxicillin to increase the efficacy.

Doubling the routinely given concentration (in pediatrics) of amoxicillin has been shown to eradicate intermediately resistant Streptococcus pneumoniae in selected infections.[1]

Amoxicillin in trihydrate form is available as capsules, chewable and dispersable tablets plus syrup and paediatric suspension for oral use, and as the sodium salt for intravenous administration. It is one of the most common antibiotics issued to children, and the sweet-tasting liquid forms are helpful where the patient might find it difficult to take tablets or capsules. It has 3 ionizable groups.

Amoxicillin and clavulanic acid
To overcome the issue of β-lactamase production by resistant organisms, amoxicillin (in either trihydrate or sodium salt forms) may be combined with clavulanic acid, typically as the potassium salt. This combination has activity against a very broad array of Gram-positive, Gram-negative, and anaerobic organisms. It is not active against MRSA, P. aeruginosa, or C. difficile. It is available in oral preparations worldwide and also in the intravenous preparation in some countries. The British Approved Name for this formulation is co-amoxiclav, but it is commonly referred to in practice by proprietary names such as Amoksiklav, Augmentin, Clamoxyl, Augclac, Augmexx, and Yucla depending on country.

Realatid Links

Buy deca-durabolin 100mg Online

Buy adderall Online

Buy Abilify Online

Buy levitra Online

Buy nalbuphine Online

Buy percocet Online

Buy prozac Online

Buy risperidone Online

Buy carisoprodol Online

Buy stelazine Online

Buy vicodin Online



Buy cephalexin Online

Buy distalgesic Online

Buy ephedrine Online

Buy imovane Online

Buy lexotanil Online

Buy eszopiclone Online

Buy nitrazepam Online

Buy noctamid Online

Buy bromazepam Online

Buy zaleplon Online

Buy phentermine Online

Buy terazosin Online

Buy ultram Online


Buy xanax Online

Buy Alprazolam Online

Buying xanax Online

Buy zedan Online

Buy zyprexa Online

Buy Augmentin Online


There are no reviews yet.

Be the first to review “AUGMENTIN 625mg”